Vancomycin
-This common antibiotic is used to treat
inflammation of the intestine (colitis).
How does it work?
-inhibition of peptidoglycan synthesis
-inhibition of peptidoglycan synthesis
The
Bactericidal action of vancomycin results primarily from inhibition of cell
wall biosynthesis. Vancomycin prevents the incorporation of N-acetylmuramice
(NAM) and N-acteylgucosamire (NAG) peptide subunits from being incorporated
into the peptidoglycan matrix, which forms the major structural component of
gram-positive cell walls.
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Erythromycin
An antibiotic used to treat certain infections caused by bacteria, such
as bronchitis, diphtheria, legionnaines diease, pneumonia, theumatic fever, renereal
disease and ear, lung, intestine, urinary tract and skin infections.
How does Erythromycin work?
-This inhibits the ribosome function
-This inhibits the ribosome function
-Erythromycin works by penetrating the
bacterial cell membrane and reversibly binding to the 50s subunit of bacterial
ribosomes or near the donor site so that binding of +RNA to the donor site is
blocked. Translocation of peptides from the “A” or acceptor site to the “p” or
donor site is prevented and subsequent protein synthesis is inhibited.
Erythromycin is effective only against actively divide organisms.
